I personally think Newgrounds is one of the large-scale, user-friendliest sites out there. Its one of the few in which they really communicate to the community and give back to them. They give out prizes and money, and talk with many people of the Newgrounds community. This is different from other large sites, like Myspace, Youtube, ect. which just put up a site and have everyone do whatever inside it.

But I guess thats just the scheme of Newgrounds compared to other sites.